Malcolm in the Middle was featured on the animated TV show Family Guy (which is often referred to as a ‘Dysfunctional Family’ like the Wilkersons). The episode titled I Take Thee, Quagmire aired March 12, 2006 (Season 4 Episode 21) and the Malcolm in the Middle scene was (in usual Family Guy style) unrelated to the rest of the episode and played as Brian (the Family Guy dog) is watching TV.

Bryan Cranston voiced the animated Hal, however Seth MacFarlane the series creator said in the DVD commentary for the episode that Jane Kaczmarek was asked to do the voice as she was the original actor in the series, however she refused. MacFarlane said that he gets a message that Kaczmarek wishes to portray that character as likeable, and does not wish to jeopardize that.

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