I agree that Fancis and Piama kind a like the new Hal and Lois.
Malcolm has made it uo to a very goog job, maybe lawyer or something like that. looking forward to become president.
Reese still lives together with craig. This is a hilarious constelation i think.
Dewey and Jamie are still at home and keep going making their parents go crazy, maybe together with the kids of francis.
In this reunion episode they all come together again, first everybody tells of their lifes and then malcolm, reese, dewey... make something really childish and stupid again. So it will end up like a "normal" episode. This depicts that somehow nothing really changed, even though they grew up.