Francis and Piama would be the new Hal and Lois, I bet.
Reese would probably still be the same dumbarse janitor, but highly adorable, like before. Hopefully he's an item with Craig and they live together with loads of cats.
I'd love Malcolm to have failed at everything... his constant arrogance was beyond annoying and I would love it if he got knocked down a few pegs!
Dewey... now, as weird as this may sound, I always thought he was highly intelligent. I could see him being enrolled in higher education.
Jamie and the other child would probably be up to no good, along with the children Francis and Piama may have had.